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Chats for science and medicine

Scientists and healthcare experts shared chats they use in their research and professional practice. Tap a chat to get started.

Brainstorm research questions

I’m a medical researcher in pediatric radiology. Based on this medical dataset and your knowledge of what top-tier journals look for, what are some compelling research questions, analyses, or novel angles I could pursue to develop a publishable paper?

Create list of gene candidates for a specific disease

List all the genes that are reported as candidates for early-onset psychosis in the scientific literature. Don’t forget preprints in medRxiv and bioRxiv.

Get up to speed quickly on a condition

Tell me everything you know about retinitis pigmentosa.

Identify medications that alter the expression of a gene

Are there any medications known to downregulate expression of the KCNQ3 gene?

Evaluate a gene candidate

I’m a geneticist specializing in rare diseases and need to prioritize candidate genes for further investigation. What is the role of PIEZO2 in bladder mechanosensation and IC/BPS pathophysiology?

Identify experimental controls

List good control genes or loci to look at methylation differences between blood and saliva sequences.

Learn how to navigate a database

I’m an academic pathologist. Walk me through how I can search for anatomic pathology cases in Epic SlicerDicer.

Identify data in a research paper

You are an expert scientist specializing in human genetics. Please carefully review the provided research paper. - Identify and tell me explicitly where the authors have deposited or provided access to the GWAS summary statistics used or generated in their study. - Include repository names, accession numbers, URLs, or specific sections of the manuscript if mentioned.

Check manuscript references

I am editing a draft of a research manuscript. Are all the references correct? Any duplicates? Does the draft include obvious errors or things that seem strange?

Identify pigments from a stain

What kind of pigment is this in the liver? At first glance, I thought it could be bile, but it’s not in the canalicular spaces. It appears to be within hepatocytes, but the distribution also doesn’t seem classic for lipofuscin.

Prepare tissue analysis

I’m a researcher specializing in gastrointestinal diseases. I’m preparing to make a tissue microarray (TMA) of resected post-neoadjuvant pancreatic ductal adenocarcinomas (PDACs). TRG3 (tumor regression grade) cases will have the most tumor volume, but it would also be good to include TRG2 and possibly some TRG1 cases as well. Assuming I can fit 12 tumor cores per TMA, want two cores per case and want to have around 100 unique cases, how many TMAs are needed? What distribution of TRG cases do you recommend if I want to guarantee that at least 80 cases have viable tumor left on a core after TMA sectioning?

Experiment with a new ratings scale for bilingual patients

I would like to build an anxiety scale from 1 to 10 and define each level in English and translate into Korean: 1–2: No anxiety 3–4: Mild anxiety 5–6: Moderate anxiety 7–8: High anxiety 9–10: Extreme anxiety (unable to think about anything other than anxiety)

Find resources for victims of crime

I have just completed a psychological evaluation report for a non-English-speaking patient who was a victim of a crime. Besides submitting my report on her behalf, what else can I do to advocate for her as a mental health professional?

Create an easy insurance guide for patients

Explain how to navigate common hospital-based insurance and billing issues for patients, like understanding deductibles, EOBs, or coding errors, in plain English with examples.

Update a policy based on today’s standards

Can you give me a primer regarding creating/revising a policy for a hospital ethics committee by today’s standards? Please refer to current best practices in the U.S. for a nonprofit community hospital. Focus on who should sit on the committee, what should trigger calling the ethics committee (routinely or emergently), the timeline for a decision, and follow-up actions of the committee.

Create a micro-lesson

I’m an assistant professor in a School of Nursing. Create a 10-minute micro-lesson for nursing students on sepsis basics. Include five key points, five teach-back questions, a three-question quiz with answers, and a “common mistakes” section.

Describe each variable in an equation

Explain this mathematical model: S(t)=f(t,θ)+N(0,σ(t)2)

Create a vector image

I’m a pathologist. Generate a high-quality vector art image of a glass pathology slide with FNA smear material on it. Vertically orient the slide, and make the background transparent.

Build a curriculum that can become a book

Let’s build a curriculum geared toward medical students and MBA students that teaches the essentials of healthcare finance, such as payer mix, RVUs, cash flow, and business modeling. The goal is to eventually turn it into a book or course.

Apply a mathematical model to your research

Tell me about the ordinary differential equation (ODE) model. How might it be used to predict oocyte consumption in the ovary?

Find scientific literature

I am an academic pathologist with a research focus in GI pathology. Summarize our current understanding of transcription factors (NEUROD1, ASCL1, POU2F3, YAP1) in high-grade neuroendocrine carcinomas, including their correlation with small cell vs. large cell NEC. I’m aware of some papers in the thoracic literature. Are there any references on this topic in the GI literature?

Make connections across scientific literature

You are a domain-expert researcher. I’m attaching several academic papers — each presenting distinct theories, datasets, or methodologies. Please: • Summarize each paper’s key findings in one or two sentences. • Identify and explain at least three non-obvious connections or thematic overlaps across the papers. • Propose at least three novel hypotheses or research ideas that emerge only when these works are considered together. For each proposed idea, outline: • a concise title • why it follows logically from the combined literature • one possible experimental or computational approach to test it Present your answer in a structured report with clearly labeled sections (Summary, Connections, New Ideas, Next Steps)

Evaluate published evidence linking two conditions

Summarize the literature on joint laxity and interstitial cystitis/bladder pain syndrome, including relevant sources. Are there any published papers describing a relationship between these two conditions?

Identify treatments to repurpose

What diseases could intravenous immunoglobulin (IVIg) possibly treat that it’s not already used for?

Analyze a large dataset

I am looking for genes that may cause urogenital disorders. I need help studying a large proteomic dataset on patient urine. Based on the attached file, do any of these cases have urine proteomic values that seem unique or drastically different from the others? If so, what is different about them?

Identify potential drug candidates

I used machine learning to identify ~50 potential treatments for POEMS syndrome. Will you assess and validate these treatments? For each treatment, let me know the biological rationale for why it may work and why it may not. Then re-rank them based on existing evidence.

Critique your research paper

Below is my manuscript. Please act as a top-tier peer reviewer and read it thoroughly: - Focus on identifying conceptual, structural, or scientific weaknesses that might lead reviewers to reject it from a high-impact journal. - Give me specific, actionable suggestions on how to revise those weak points. - Recommend a shortlist of appropriate journals for submission.

Translate your research into layman’s language

Read this paper very carefully, reason about it, then write a report in layman’s language that captures all the important points and why this research is significant or impactful to the field. Explain what this means for therapeutics and diagnosis for ME/CFS.

Generate personalized pictures for test stimuli

Create an image for a cognitive assessment that is culturally appropriate and clear for people to describe based on the following guidance: A clean, horizontal digital artwork of an indoor community space in soft, semi-stylized illustration style (not realistic). The scene includes exactly 12 unique content units: 4 people, each performing a completely different activity (e.g., reading, painting, stretching, watering a plant) and 8 distinct inanimate objects (e.g., potted plant, wall art, rug, bookshelf, window, chair, table with supplies, floor lamp). Each person and object must be fully visible and clearly different — no repetitions in action, object, or appearance. Distribute the content evenly across the image with exactly 3 content points in each quadrant (upper left, upper right, lower left, lower right). Use soft colors, clear separation between elements, and a warm, family-friendly tone. The image should be free of text and easy to interpret visually, especially on a mobile screen.

Brainstorm treatment options

I’m drafting proposed care guidelines for my academic paper. Suggest evidence-based alternative care options for nausea in pregnant women between 8 and 16 weeks, including when symptoms require escalation.

Find culturally sensitive alternatives to a procedure

I’m an advanced nurse practitioner. Help me find evidence-based medical alternatives to blood transfusion that are acceptable to Jehovah’s Witnesses, including treatments supported in clinical guidelines.

Get a crash course

I am interested in the Chief Medical Officer role at a nonprofit community hospital. Please give me a crash course on what I need to know, with an emphasis on how current legislation has or may impact healthcare delivery and what that means for a CMO.

Simulate a 12-hour ER shift

Help me design a 12-hour shift simulation for the emergency department, where ChatGPT assists with triage priorities, patient education, and documentation cues.

Simplify patient documentation

I work in the ER. Suggest ways to streamline nursing charting for a 12-hour shift, including examples of efficient documentation templates or time-saving phrasing.

Design a course

I’m designing a healthcare education module for high school students to understand how AI can assist medical professionals. Can you help me create an engaging worksheet that introduces AI in nursing and includes a simple ethical scenario for discussion?

Convert data to a different schema

I need to map incoming HL7v2 messages to valid R4 FHIR. I have provided deidentified messages in a ZIP file for incoming analysis.

Brainstorm next-generation treatments

You are a world‐leading expert in HIV, immunology, and therapeutic development. Your goal is to map out 10 clear paths that, if pursued rigorously, could finally solve the HIV cure/vaccine challenge. Develop and describe 10 distinct, high‐impact approaches—ranging from novel immunogens and delivery platforms to cell- and gene-based therapies—that could realistically lead to either a functional cure or an effective vaccine. For each approach, include: • A concise name or concept title • Underlying biological rationale • Key technological or methodological innovation • Anticipated mechanism of action • Major technical or safety challenges and how to address them • A rough timeline or next‐step experiment to validate feasibility Be bold, interdisciplinary, and specific.

Identify cell inhibitors

I’m a medical researcher and physician exploring repurposed treatments for a deadly condition where NK cells seem to be highly activated. What drugs inhibit or kill NK cells?

Create a reading list

Make a list of the top literature from 2024 on AI and healthcare. “Top” can mean anything from an exciting topic to an extremely useful method to a dataset that enables new and important research. With the list, please include the reason the paper was chosen.

Synthesize findings on a specific area of research

I’m a reproductive geneticist and stem cell researcher, developing a new research plan. Summarize the existing literature on protein aggregation in oocytes.

Research a possible gene candidate for a disease

I’m a geneticist specializing in rare disease gene discovery. [Gene name redacted] is interesting as a candidate for hypophosphatemic rickets. Please summarize the literature on this gene and evaluate whether it is a good candidate for causing hypophosphatemic rickets. What mechanism might explain such an association?

Get an early read on experimental results

In my latest experiment, lactose synthesis appears to be elevated in dormant oocytes. What does this imply?

Compare data file formats

For raw molecular sequencing results, is the BAM or FASTQ file format better? Is one format easier to analyze? Compare the pros and cons of the two.

Identify relevant literature to cite

I want to make sure I am citing the most recent and relevant literature. Please provide appropriate references for the following statement: Sexual differentiation is first initiated within a subset of gonadal somatic cells, which subsequently adopt sex-specific fates. In males, Sry expression directs differentiation into Sertoli cells; whereas in females, the absence of Sry leads to granulosa cell differentiation.

Get a gut check on your peer-review response

I’ve responded to comments from reviewers of my research paper. I have uploaded the original reviews and my response. Did I miss anything?

Search for FDA-approved drugs

Can you provide the names of FDA-approved drugs that inhibit the following pathways, which I just found to be enriched in a particular disease?

Create content for a clinical research study

I’m generating a word list recall for a memory test. Create a list of 10 words in American English at a sixth-grade reading level, each with a moderate level of word frequency.

Tailor a meal plan for your patient

I am a family physician giving dietary advice to a 46-year-old man who is unhoused and lives out of his vehicle. He works at a local gas station and has diabetes and hypertension. He has no access to refrigeration. He can only cook on a charcoal grill. His monthly food budget is $250. - Please estimate realistic price ranges for staples he can reasonably access, such as canned, dried, and shelf-stable foods that can be cooked on a grill. - Identify foods and combinations appropriate for both diabetes and high blood pressure, focusing on low sodium, complex carbohydrates, high fiber, and lean protein choices that fit his living situation. - Develop a practical one-week rotating meal plan including breakfast, lunch, dinner, and snacks that can be prepared with minimal equipment and no refrigeration.

Review hospital patient guidance

Summarize recent clinical research or expert guidelines about hospital patient vaccination protocols, especially findings that go beyond standard local hospital protocols.

Design a roadmap

You are a healthcare operations strategist and clinical informaticist. Design a sustainable primary-care clinic model for a 3,500-patient rural/suburban panel with about 50% Medicare coverage, limited in-house ancillary staff, and APP shortages. - Optimize for continuity, same-day access, and financial viability under realistic FFS + TCM + RPM assumptions (CCM optional). - Include team structure, visit flow, access strategy, projected CPT mix and revenue, quality metrics, and practical ways AI automation could reduce workload. Conclude with a 90-day implementation roadmap.

Brainstorm research projects for your trainees

I am an academic pathologist with a research focus in GI pathology. Help me brainstorm some new research project ideas suitable for trainees of different levels, such as a new PGY1 resident, a senior resident, and a fellow. Note that more junior trainees probably need smaller, less complex projects but have the longest time to work on a project. Fellows are the most experienced but have less than a year, so would need a more self-contained project.

Explore how to build a prototype

I want to prototype a healthcare data exchange from scratch. Help me reason through the high-level architecture, including ingestion, validation, transformation, compliance considerations, and operational concerns like scale and reliability.

Debate big questions

Does AI-assisted scientific authorship add to the scientific method, or should it be approached with caution? Write a short reflection. Consider such topics as transparency, reproducibility, and human-AI collaboration.